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KMID : 0363819720060020041
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Korean Journal of Nuclear Medicine
1972 Volume.6 No. 2 p.41 ~ p.47
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Radioimmunoassay of Human Thyrotropin
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高昌舜/Koh, Chang Soon
李弘揆/盧興圭/李文鎬/Lee, Hong Hyu/Ro, Heung Kyu/Lee, Munho
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Abstract
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The radioimmunoassay of human thyrotropin was performed in various thyroid states, utilizing the anti--´h-T.S.H. antibody and purified human thyrotropin supplied from National Institute of Arthritis and Metabolic Diseases, Bethesda, Ma., U.S.A., and human thyrotropin standard-A obtained from National Institute for Biologic Standards, Mill Hill, London, England. 1311 labelled h-TSH was prepared after the Chloramine-T method of Greenwood et al.
This double antibody system had a assay sensitivity of about 1.0 pU/ml of plasma HTS-A and could detect the plasma h-TSH level in the euthyroid patients.
Plasma h-TSH level of the normal 26 Korean was 1. 1±0.83 pU/ml, and that of the 8 h th
ypo yroi
diems-were´8:3 to 67.5pU/ml. In hyperthyroidisms, no cases showed the plasma h-TSH levels over 1.0 pU[ml. Between the hypothyroidism and euthyroidsm, no overlap is noticed on plasma h-TSH
A case of transient hypothyroid state identified by determination of plasma h-TSH level is presented. These results-revealed that the radioimmunoassay of h-TSH in plasma could be a sensitive method ´to diagnoseethe hypothyroidsm, ´if not caused by a pituitary disease.
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